Article
CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2011
Huang Rong Rong, Jalil Jason, Economou James S, Chmielowski Bartosz, Koya Richard C, Mok Stephen, Sazegar Hooman, Seja Elizabeth, Villanueva Arturo, Gomez-Navarro Jesus, Glaspy John A, Cochran Alistair J, Ribas Antoni
Abstract excerpt
BACKGROUND: CTLA4 blocking monoclonal antibodies provide durable clinical benefit in a subset of patients with advanced melanoma mediated by intratumoral lymphocytic infiltrates. A key question is defining whether the intratumoral infiltration (ITI) is a differentiating factor between patients with and without tumor responses. METHODS: Paired baseline and postdosing tumor biopsy specimens were prospectively...
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