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Article

Creation of new metabolic pathways or improvement of existing metabolic enzymes by in vivo evolution in Escherichia coli.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Meynial-Salles Isabelle, Soucaille Philippe

Abstract excerpt

A method for in vivo evolution of metabolic pathways in bacteria is described. This method is a powerful tool for synthetic biology type of metabolic design and can lead to the creation of new metabolic pathways or the improvement of existing metabolic enzymes. The proposed strategy also permits to relate the evolved phenotype to the genotype and to analyze evolution phenomenon at the genetic, biochemical, and...

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PMID: 22144354
DOI: 10.1007/978-1-61779-483-4_6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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