Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Repeated transplantation of hepatocytes prevents fulminant hepatitis in a rat model of Wilson's disease.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Feb 2012

Sauer Vanessa, Siaj Ramsi, Stöppeler Sandra, Bahde Ralf, Spiegel Hans-Ullrich, Köhler Gabriele, Zibert Andree, Schmidt Hartmut H J

Abstract excerpt

The outcome of consecutive hepatocyte transplants was explored in a rat model of Wilson's disease before the onset of fulminant hepatitis without preconditioning regimens. Rats received a high-copper diet in order to induce a rapid induction of liver failure. Sham-operated rats (15/15) developed jaundice and fulminant hepatitis, and they died within 4 weeks of first transplantation. Despite the continuation of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Rats, Long-Evans
Share to Copper

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Copper-Transporting ATPases

Share to Hepatitis

Share to Hepatocytes

Share to Hepatolenticular Degeneration

Share to Rats, Transgenic

Share to Reoperation

Source

Identifiers

PMID: 22140056
DOI: 10.1002/lt.22466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repeated transplantation of hepatocytes prevents fulminant hepatitis in a rat model of Wilson's disease.PMID 22140056Read ↗

Hepatocyte transplantation in the Long Evans Cinnamon rat model of Wilson's disease.Semantic proximity Read ↗

ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson's disease.Semantic proximity Read ↗

Liver cell transplantation leads to repopulation and functional correction in a mouse model of Wilson's diseaseSemantic proximity Read ↗

Demonstrating Potential of Cell Therapy for Wilson's Disease with the Long-Evans Cinnamon Rat Model.Semantic proximity Read ↗

Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson’s diseaseSemantic proximity Read ↗

Long-term outcomes for 32 cases of Wilson's disease after living-donor liver transplantation.Semantic proximity Read ↗

Repeated dosing of AAV-mediated liver gene therapy in juvenile rat and mouse models of Crigler-Najjar syndrome type ISemantic proximity Read ↗

Critical assessment of lifelong phenotype correction in hyperbilirubinemic Gunn rats after retroviral mediated gene transfer.Semantic proximity Read ↗

Methanobactin reverses acute liver failure in a rat model of Wilson disease.Semantic proximity Read ↗

Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma.Semantic proximity Read ↗

Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat.Semantic proximity Read ↗

Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.