Article
Capillary electrophoresis of an 11-plex mtDNA coding region SNP single base extension assay for discrimination of the most common Caucasian HV1/HV2 mitotype.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Vallone Peter M
Abstract excerpt
The typing of single nucleotide polymorphisms (SNPs) located throughout the human mitochondrial genome assists in resolving individuals with an identical HV1/HV2 haplotype. A set of 11 sites which were selected for distinguishing individuals of a common Western European Caucasian HV1/HV2 mitotype was incorporated into a single base extension (SBE) assay. The assay was optimized for multiplex detection of sequence...
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