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High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder

8 Apr 2009

Abstract excerpt

Familial platelet disorder (FPD), a rare autosomal dominant disorder characterized by quantitative and qualitative platelet abnormalities, is considered as a model of genetic predisposition to acute myeloid leukemia (AML). So far, monoallelic RUNX1 germline mutations have been found in 19 of 20 families with reported FPD, and the analysis of blast cells from only 5 patients at acute leukemia (AL) stage has shown...

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PMID: 19357396
DOI: 10.1182/blood-2008-07-168260

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