Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Familial myelodysplasia and acute myeloid leukaemia--a review.

British journal of haematology - 1 Jan 2008

Owen Carolyn, Barnett Michael, Fitzgibbon Jude

Abstract excerpt

Familial occurrence of myelodysplasia (MDS) and/or acute myeloid leukaemia (AML) is rare but can provide a useful resource for the investigation of predisposing mutations in these myeloid malignancies. To date, examination of families with MDS/AML has lead to the detection of two culprit genes, RUNX1 and CEBPA. Germline mutations in RUNX1 result in familial platelet disorder with propensity to myeloid malignancy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Proteins
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Neoplastic Syndromes, Hereditary

Share to Pedigree

Source

Identifiers

PMID: 18173751
DOI: 10.1111/j.1365-2141.2007.06909.x

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Familial myelodysplasia and acute myeloid leukaemia--a review.PMID 18173751Read ↗

Familial myelodysplastic syndromes: a review of the literatureSemantic proximity Read ↗

Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations.Semantic proximity Read ↗

[Clinical and genetic background of familial myelodysplasia and acute myeloid leukemia].Semantic proximity Read ↗

Familial Acute Myeloid Leukemia and Myelodysplasia in Hungary.Semantic proximity Read ↗

Familial risks of acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms.Semantic proximity Read ↗

Genetic predisposition to myelodysplastic syndrome and acute myeloid leukemia in children and young adults.Semantic proximity Read ↗

Hereditary Predispositions to Myelodysplastic Syndrome.Semantic proximity Read ↗

Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy.Semantic proximity Read ↗

Proposal for the clinical detection and management of patients and their family members with familial myelodysplastic syndrome/acute leukemia predisposition syndromesSemantic proximity Read ↗

Genetic predisposition to myelodysplastic syndrome: Genetic counseling and transplant implications.Semantic proximity Read ↗

Familial platelet disorder with propensity to acute myelogenous leukemia: genetic heterogeneity and progression to leukemia via acquisition of clonal chromosome anomalies.Semantic proximity Read ↗

A de novo germline RUNX1 variant preceding development of concurrent T-lymphoblastic leukemia and myelodysplastic syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.