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Article

Inactivation of MYO5B promotes invasion and motility in gastric cancer cells.

Digestive diseases and sciences - 1 May 2012

Dong Wenjie, Chen Xiaobing, Chen Ping, Yue Dongli, Zhu Linan, Fan Qingxia

Abstract excerpt

BACKGROUND: Loss of cell polarity and tissue disorganisation are hallmarks of cancer. MYO5B mutations disrupt epithelial cell polarity, suggesting that MYO5B may be involved in tumorigenesis. METHODS: We analyzed MYO5B expression in 70 gastric cancer tissues by immunohistochemistry using a tissue microarray method. Two related proteins, Rab11a and TfR, were also investigated. RESULTS: We found that the negative...

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Identifiers

PMID: 22134786
DOI: 10.1007/s10620-011-1989-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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