Article
Altered closed state inactivation gating in Kv4.2 channels results in developmental and epileptic encephalopathies in human patients.
Human mutation - 1 Sept 2022
Bavan Selvan, Goodkin Howard P, Papazian Diane M
Abstract excerpt
Kv4.2 subunits, encoded by KCND2, serve as the pore-forming components of voltage-gated, inactivating ISA K+ channels expressed in the brain. ISA channels inactivate without opening in response to subthreshold excitatory input, temporarily increasing neuronal excitability, the back propagation of action potentials, and Ca2+ influx into dendrites, thereby regulating mechanisms of spike timing-dependent synaptic...
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