Article
Bone morphogenetic protein receptor 2 in patients with idiopathic portal hypertension.
Journal of cellular and molecular medicine - 1 Sept 2012
De Gottardi Andrea, Seijo Susana, Milá Montserrat, Alvarez M Isabel, Bruguera Miquel, Abraldes Juan G, Bosch Jaime, García-Pagán Juan-Carlos
Abstract excerpt
In idiopathic portal hypertension (IPH) typical vascular lesions are present in the branches of the portal vein or in the perisinusoidal area of the liver. Similar histological alterations have been reported in the pulmonary vasculature of patients with idiopathic pulmonary artery hypertension (IPAH). As IPAH is associated with mutations of the bone morphogenetic protein receptor 2 (BMPR2) gene, the aim of this...
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