Article
Absence of influence of gender and BMPR2 mutation type on clinical phenotypes of pulmonary arterial hypertension.
Respiratory research - 10 Jun 2010
Girerd Barbara, Montani David, Eyries Mélanie, Yaici Azzedine, Sztrymf Benjamin, Coulet Florence, Sitbon Olivier, Simonneau Gérald, Soubrier Florent, Humbert Marc
Abstract excerpt
BACKGROUND: Previous studies indicate that patients with pulmonary arterial hypertension (PAH) carrying a mutation in the bone morphogenetic protein receptor type 2 (BMPR2) gene, develop the disease 10 years earlier than non-carriers, and have a more severe hemodynamic compromise at diagnosis. A recent report has suggested that this may only be the case for females and that patients with missense mutations in...
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