Article
Hemodynamic and clinical onset in patients with hereditary pulmonary arterial hypertension and BMPR2 mutations.
Respiratory research - 29 Jul 2011
Pfarr Nicole, Szamalek-Hoegel Justyna, Fischer Christine, Hinderhofer Katrin, Nagel Christian, Ehlken Nicola, Tiede Henning, Olschewski Horst, Reichenberger Frank, Ghofrani Ardeschir H A, Seeger Werner, Grünig Ekkehard
Abstract excerpt
BACKGROUND: Mutations in the bone morphogenetic protein receptor 2 (BMPR2) gene can lead to idiopathic pulmonary arterial hypertension (IPAH). This study prospectively screened for BMPR2 mutations in a large cohort of PAH-patients and compared clinical features between BMPR2 mutation carriers and non-carriers. METHODS: Patients have been assessed by right heart catheterization and genetic testing. In all patients...
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