Article
Genomic profiling of B-progenitor acute lymphoblastic leukemia.
Best practice & research. Clinical haematology - 1 Dec 2011
Mullighan Charles G
Abstract excerpt
Childhood acute lymphoblastic leukemia (ALL) is comprised of multiple subtypes defined by recurring chromosomal alterations that are important events in leukemogenesis and are widely used in diagnosis and risk stratification, yet fail to fully explain the biology of this disease. In the last 5 years, genome-wide profiling of gene expression, structural DNA alterations and sequence variations has yielded important...
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