Article
Worldwide distribution of allelic variation at the progesterone receptor locus and the incidence of female reproductive cancers.
American journal of human biology : the official journal of the Human Biology Council - 1 Jan 2000
Rockwell L Christie, Rowe Elizabeth J, Arnson Katherine, Jackson Fatimah, Froment Alain, Ndumbe Peter, Seck Binteou, Jackson Robert, Lorenz Joseph G
Abstract excerpt
OBJECTIVES: Global patterns of the incidence of cancer are often attributed to environmental and lifestyle differences between regions. Less attention has been given to global patterns of allelic variation of genes that may contribute to the risk of developing cancer. METHODS: We genotyped samples from 21 populations for four variants of the progesterone receptor (PR) gene. One is an Alu insertion in intron 7...
Topics
- Alleles
- Alu Elements
- Amino Acid Substitution
- Breast Neoplasms
- Female
- Gene Frequency
- Genetic Variation
- Genotype
- Haplotypes
- Humans
- Incidence
- Introns
- Ovarian Neoplasms