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Article

Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach.

Carcinogenesis - 1 Aug 2010

Lee Eunjung, Hsu Chris, Haiman Christopher A, Razavi Pedram, Horn-Ross Pamela L, Van Den Berg David, Bernstein Leslie, Le Marchand Loic, Henderson Brian E, Setiawan V Wendy, Ursin Giske

Abstract excerpt

BACKGROUND: It is well established that estrogen increases endometrial cancer risk, whereas progesterone opposes the estrogen effects. The PROGINS allele of the progesterone receptor (PGR) gene reduces the function of PGR and has been associated with increased risk of the endometrioid type ovarian cancer. We investigated whether genetic variation in PGR is also associated with endometrial cancer risk using a...

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Source

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Identifiers

PMID: 20547493
DOI: 10.1093/carcin/bgq113
PMCID: PMC2915632

Genes

PGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach.PMID 20547493Read ↗

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Progesterone receptor gene variants and risk of endometrial cancer.Semantic proximity Read ↗

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