Article
Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.
British journal of cancer - 29 Jan 2008
Pearce C L, Wu A H, Gayther S A, Bale A E, Beck P A, Beesley J, Chanock S, Cramer D W, DiCioccio R, Edwards R, Fredericksen Z S, Garcia-Closas M, Goode E L, Green A C, Hartmann L C, Hogdall E, Kjaer S K, Lissowska J, McGuire V, Modugno F, Moysich K, Ness R B, Ramus S J, Risch H A, Sellers T A, Song H, Stram D O, Terry K L, Webb P M, Whiteman D C, Whittemore A S, Zheng W, Pharoah P D P, Chenevix-Trench G, Pike M C, Schildkraut J, Berchuck A
Abstract excerpt
There is evidence that progesterone plays a role in the aetiology of invasive epithelial ovarian cancer. Therefore, genes involved in pathways that regulate progesterone may be candidates for susceptibility to this disease. Previous studies have suggested that genetic variants in the progesterone receptor gene (PGR) may be associated with ovarian cancer risk, although results have been inconsistent. We have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.