Article
Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas.
The Journal of clinical investigation - 1 Oct 1990
Smidt M, Kirsch I, Ratner L
Abstract excerpt
An abnormality in the c-sis protooncogene was identified in leukocyte DNA from members of a family predisposed to the development of meningioma, and was found to be associated with the development of the tumor in those individuals. Molecular analysis of this abnormality demonstrated a deletion wi...
Topics
- Alleles
- Base Sequence
- Chromosome Deletion
- Humans
- Introns
- Meningeal Neoplasms
- Meningioma
- Molecular Sequence Data
- Platelet-Derived Growth Factor
- Polymerase Chain Reaction
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-sis
- Proto-Oncogenes
- Repetitive Sequences, Nucleic Acid