Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas.

doi:10.1172/JCI114820

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Article

Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas.

The Journal of clinical investigation - 1 Oct 1990

Smidt M, Kirsch I, Ratner L

Abstract excerpt

An abnormality in the c-sis protooncogene was identified in leukocyte DNA from members of a family predisposed to the development of meningioma, and was found to be associated with the development of the tumor in those individuals. Molecular analysis of this abnormality demonstrated a deletion within the fifth intron of the c-sis gene. The normal c-sis gene has an Alu sequence in this region which includes two...

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