Common variation at 10p12.31 near MLLT10 influences meningioma risk.

doi:10.1038/ng.879

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Article

Common variation at 10p12.31 near MLLT10 influences meningioma risk.

Nature genetics - 31 Jul 2011

Dobbins Sara E, Broderick Peter, Melin Beatrice, Feychting Maria, Johansen Christoffer, Andersson Ulrika, Brännström Thomas, Schramm Johannes, Olver Bianca, Lloyd Amy, Ma Yussanne P, Hosking Fay J, Lönn Stefan, Ahlbom Anders, Henriksson Roger, Schoemaker Minouk J, Hepworth Sarah J, Hoffmann Per, Mühleisen Thomas W, Nöthen Markus M, Moebus Susanne, Eisele Lewin, Kosteljanetz Michael, Muir Kenneth, Swerdlow Anthony, Simon Matthias, Houlston Richard S

Abstract excerpt

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21804547
DOI: 10.1038/ng.879
PMCID: PMC5053355

Genes

MLLT10

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