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Quantitative 3D Tracing of Gene-delivery Viral Vectors in Human Cells and Animal Tissues

22 Nov 2011

Abstract excerpt

Trafficking through a variety of cellular structures and organelles is essential for the interaction between gene-delivery vectors (i.e., adeno-associated virus (AAV) and liposomes) and host cells/tissues. Here, we present a method of computer-assisted quantitative 3D biodistribution microscopy that samples the whole population of fluorescently-labeled vectors and document their trafficking routes. Using AAV as a...

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PMID: 22108857
DOI: 10.1038/mt.2011.250

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