Article
Inherited thrombocytopenia due to GATA-1 mutations.
Seminars in thrombosis and hemostasis - 1 Sept 2011
Millikan Patrick D, Balamohan Sanjeev M, Raskind Wendy H, Kacena Melissa A
Abstract excerpt
The GATA family of transcription factors, including the founding member, GATA-1, have an important role in gene regulation. GATA-1 is integral to successful hematopoiesis. A wide variety of mutations in GATA-1 affect its function, as well as its interaction with its cofactors (especially Friend of GATA) and the genes upon which GATA-1 acts. Here we review the known mutations, focusing on the specific alterations...
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