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Article

Importance of the proline-rich multimerization domain on the oligomerization and nucleic acid binding properties of HIV-1 Vif.

Nucleic acids research - 1 Mar 2011

Bernacchi Serena, Mercenne Gaëlle, Tournaire Clémence, Marquet Roland, Paillart Jean-Christophe

Abstract excerpt

The HIV-1 viral infectivity factor (Vif) is required for productive infection of non-permissive cells, including most natural HIV-1 targets, where it counteracts the antiviral activities of the cellular cytosine deaminases APOBEC-3G (A3G) and A3F. Vif is a multimeric protein and the conserved proline-rich domain (161)PPLP(164) regulating Vif oligomerization is crucial for its function and viral infectivity. Here,...

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Identifiers

PMID: 21076154
DOI: 10.1093/nar/gkq979
PMCID: PMC3064812

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Source receipt: pubmed, retrieved 7 Sept 2026.

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