Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PON1 Q192R and clopidogrel: a case of the winner's curse or inadequate replication?

Clinical pharmacology and therapeutics - 1 Dec 2011

Talameh J A, McLeod H L

Abstract excerpt

The antiplatelet drug clopidogrel is one of the most commonly prescribed drugs in the world, but there is wide interpatient variability in its antiplatelet effects. The majority of this variation is due to genetic effects, but there is controversy over which genetic variants are important and their relative contribution. This controversy may stem from the genetic association research paradigm, which casts the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryldialkylphosphatase
Share to Cardiovascular Diseases
Share to PON1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genetic Variation

Share to Myocardial Infarction

Share to Polymorphism, Genetic

Share to Ticlopidine

Source

Identifiers

PMID: 22089342
DOI: 10.1038/clpt.2011.226

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PON1 Q192R and clopidogrel: a case of the winner's curse or inadequate replication?PMID 22089342Read ↗

Genetic and nongenetic factors influencing the response to clopidogrel.Semantic proximity Read ↗

Pharmacogenomics of clopidogrel: evidence and perspectives.Semantic proximity Read ↗

Association between Q192R PON1 genetic polymorphism and major adverse cardiovascular events in patients treated with clopidogrel: an updated meta-analysis.Semantic proximity Read ↗

Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.Semantic proximity Read ↗

Current controversies in the pharmacogenomics of clopidogrel.Semantic proximity Read ↗

Relationship between paraoxonase-1 activity, its Q192R genetic variant and clopidogrel responsiveness in the ADRIE study.Semantic proximity Read ↗

The diversity and clinical implications of genetic variants influencing clopidogrel bioactivation and response in the Emirati population.Semantic proximity Read ↗

PON1 Q192R genotype influences clopidogrel responsiveness by relative platelet inhibition instead of on-treatment platelet reactivity.Semantic proximity Read ↗

Pharmacogenetics of Clopidogrel: An Unresolved Issue.Semantic proximity Read ↗

PON1 Q192R is associated with high platelet reactivity with clopidogrel in patients undergoing elective neurointervention: A prospective single-center cohort study.Semantic proximity Read ↗

CYP2C19 genotype-guided antiplatelet therapy: promises and pitfalls.Semantic proximity Read ↗

Genetic and Clinical Determinants of MACE and Haemorrhage in Antiplatelet Therapy: Insights from Pharmacogenomic AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.