Article
Investigation of ABCB1 1236 and 2677 SNPs in patients with peptic ulcer.
Scandinavian journal of gastroenterology - 1 Jan 2012
Żebrowska Marta, Jażdżyk Marcin, Sałagacka Aleksandra, Balcerczak Mariusz, Janiuk Robert, Mirowski Marek, Balcerczak Ewa
Abstract excerpt
OBJECTIVE: P-gp, encoded by ABCB1 gene, is an ATP-binding membrane pump, which exports substrates from the cell including drugs and xenobiotics. Changes in the function of P-gp as a result of polymorphism could have an impact in some diseases' risks and treatment outcomes. The aim of the study was to determine the significance of the ABCB1 gene SNPs: 1236 and 2677 for peptic ulcer risk and development of...
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