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Article

The elusive management of an individual patient with SCN9A sodium channelopathy in the perioperative setting.

Pain - 1 Sept 2026

Wadle Michael, Szafarowicz Bianca, Nykiel-Bailey Sydney, Tan Brandon, AuBuchon Jacob, Njoku Dolores

Abstract excerpt

ABSTRACT: Mutations in the SCN9A gene, which encodes the sodium voltage-gated channel alpha subunit 9 on chromosome 2 (Nav1.7), are extremely rare and play a crucial role in pain signaling. Depending on the type of mutation, the clinical presentation of these mutations can vary widely from hyperactive pain phenotypes such as primary erythromelalgia to hypoactive pain phenotypes manifesting as congenital...

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Identifiers

PMID: 42294779
DOI: 10.1097/j.pain.0000000000004026

Genes

SCN9A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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The elusive management of an individual patient with SCN9A sodium channelopathy in the perioperative setting.PMID 42294779Read ↗

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