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Article

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

The Journal of biological chemistry - 2 Jan 2012

Canals Meritxell, Lane J Robert, Wen Adriel, Scammells Peter J, Sexton Patrick M, Christopoulos Arthur

Abstract excerpt

The Monod-Wyman-Changeux (MWC) model was initially proposed to describe the allosteric properties of regulatory enzymes and subsequently extended to receptors. Yet despite GPCRs representing the largest family of receptors and drug targets, no study has systematically evaluated the MWC mechanism as it applies to GPCR allosteric ligands. We reveal how the recently described allosteric modulator, benzyl quinolone...

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Identifiers

PMID: 22086918
DOI: 10.1074/jbc.M111.314278
PMCID: PMC3249119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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