Article
Down-regulation of mitogen-inducible gene 6, a negative regulator of EGFR, enhances resistance to MEK inhibition in KRAS mutant cancer cells.
Cancer letters - 1 Mar 2012
Yoon Young-Kwang, Kim Hwang-Phill, Song Sang-Hyun, Han Sae-Won, Oh Do Youn, Im Seock-Ah, Bang Yung-Jue, Kim Tae-You
Abstract excerpt
Previously, we found that KRAS mutant cancer cells showed variable response to AZD6244, a MEK inhibitor through differential activation of EGFR/AKT. To investigate its mechanism, we performed cDNA microarray using four KRAS mutant cancer cells. We found that treatment with AZD6244 reduced the expression of mitogen-inducible gene 6 (MIG6), a negative feedback regulator for EGFR, in AZD6244-resistant cells, while...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.