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Article

High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886).

Cancer biology & therapy - 1 Nov 2009

Meng Jieru, Peng Henry, Dai Bingbing, Guo Wei, Wang Li, Ji Lin, Minna John D, Chresta Christine M, Smith Paul D, Fang Bingliang, Roth Jack A

Abstract excerpt

MEK/ERK activities are increased in many primary lung cancers, and MEK inhibitors have been tested clinically for treatment of non-small cell lung cancers. The molecular mechanisms of resistance to MEK inhibitors have not been clearly demonstrated, however, and no molecular biomarker that can pre...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19783898
DOI: 10.4161/cbt.8.21.9844
PMCID: PMC2835993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19783898-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886).PMID 19783898Read ↗

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