Article
Clonotypic heterogeneity in cutaneous T-cell lymphomas.
Cancer research - 15 Oct 1990
Bignon Y J, Souteyrand P, Roger H, Fonck Y, Bernard D, Chassagne J, Ramos F, D'Incan M, Chollet P, Dastugue B
Abstract excerpt
The antigen receptor genes studied (immunoglobulin gene for B-cells, and T-cell receptor -beta or -gamma gene for T-cells) represent the most powerful tools for diagnosing the clonality of a lymphoid lineage. We have clonotyped 23 cutaneous T-cell lymphomas and 5 were found to be clonotypically all heterogeneous. Analysis of each patient was performed either from serial skin biopsies taken several months apart or...
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