Article
Genotypic analysis of T-cell clones derived from cutaneous T-cell lymphoma lesions demonstrates selective growth of tumor-infiltrating lymphocytes.
The Journal of investigative dermatology - 1 Jul 1990
Ho V C, Baadsgaard O, Elder J T, Hansen E R, Hanson C A, Vejlsgaard G L, Cooper K D
Abstract excerpt
The nature of T cells contained within cutaneous lesions of cutaneous T-cell lymphoma (CTCL) has not been studied at the clonal level. T cells extracted from skin lesions of two CTCL patients were cloned by limiting dilution and propagated in interleukin-2 (IL-2) containing medium with periodic lectin stimulation. Twelve T-cell clones were derived from each patient. In both cases, genotypic analysis of the T-cell...
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