Article
Pharmacogenetic risk for adverse reactions to irinotecan in the major ethnic populations of Singapore: regulatory evaluation by the health sciences authority.
Drug safety - 1 Dec 2011
Sung Cynthia, Lee Pui Ling, Tan Liesbet L, Toh Dorothy S L
Abstract excerpt
BACKGROUND: For genetic polymorphisms known to alter drug effect or safety, regulatory authorities can tap into population genomic databases and other sources of allele and genotype distribution data to make a more informed decision about the anticipated impact of such variants on the main ethnic groups in a country's population. OBJECTIVE: The aim of this short communication is to describe how the Singapore...
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