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Article

Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator.

Journal of medicinal chemistry - 22 Dec 2011

Alkhouri Bashar, Denning Robert A, Kim Chiaw Patrick, Eckford Paul D W, Yu Wilson, Li Canhui, Bogojeski Jovanka J, Bear Christine E, Viirre Russell D

Abstract excerpt

Cystic fibrosis is a genetic disease caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In vitro experiments have demonstrated that 4-methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol (VRT-532, 1) is able to partially restore the function of mutant CFTR proteins. To help elucidate the nature of the interactions between 1 and mutant CFTR, molecular probes based on...

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Identifiers

PMID: 22074181
DOI: 10.1021/jm201335c
PMCID: PMC3241338

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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