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Article

Capturing the Direct Binding of CFTR Correctors to CFTR by Using Click Chemistry.

Chembiochem : a European journal of chemical biology - 21 Sept 2015

Sinha Chandrima, Zhang Weiqiang, Moon Chang Suk, Actis Marcelo, Yarlagadda Sunitha, Arora Kavisha, Woodroofe Koryse, Clancy John P, Lin Songbai, Ziady Assem G, Frizzell Raymond, Fujii Naoaki, Naren Anjaparavanda P

Abstract excerpt

Cystic fibrosis (CF) is a lethal genetic disease caused by the loss or dysfunction of the CF transmembrane conductance regulator (CFTR) channel. F508del is the most prevalent mutation of the CFTR gene and encodes a protein defective in folding and processing. VX-809 has been reported to facilitate the folding and trafficking of F508del-CFTR and augment its channel function. The mechanism of action of VX-809 has...

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Identifiers

PMID: 26227551
DOI: 10.1002/cbic.201500123
PMCID: PMC4672727

Genes

CFTR
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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