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Article

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis.

European journal of medicinal chemistry - 24 Jun 2015

Pesce Emanuela, Bellotti Marta, Liessi Nara, Guariento Sara, Damonte Gianluca, Cichero Elena, Galatini Andrea, Salis Annalisa, Gianotti Ambra, Pedemonte Nicoletta, Zegarra-Moran Olga, Fossa Paola, Galietta Luis J V, Millo Enrico

Abstract excerpt

The cystic ﬁbrosis transmembrane conductance regulator (CFTR) is a chloride channel present in the membrane of epithelial cells. Mutations affecting the CFTR gene cause cystic fibrosis (CF), a multi-organ severe disease. The most common CF mutation, F508del, impairs the processing and activity (g...

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Source

Identifiers

PMID: 26041577
DOI: 10.1016/j.ejmech.2015.05.030

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26041577-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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