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Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation

15 Nov 2011

Abstract excerpt

von-Hippel Lindau protein (pVHL) suppresses tumorigenesis in the kidney, in part through regulation of hypoxia-inducible factor alpha (HIF alpha). However, HIF has been proposed to be necessary but insufficient for renal tumorigenesis. p53 was implicated as a transcription factor that is regulated by pVHL, but the molecular mechanism by which pVHL regulates p53 on DNA damage is unknown. We demonstrated that...

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PMID: 22071692
DOI: 10.4161/cc.10.22.18096

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