Article
MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts.
Human reproduction (Oxford, England) - 1 Jan 2012
Segerer S E, Rieger L, Kapp M, Dombrowski Y, Müller N, Dietl J, Kämmerer U
Abstract excerpt
BACKGROUND: Macrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 is thought to provide pleiotropic functions in the establishment and maintenance of pregnancy. So far, little is known about the decidual cell subsets producing MIC-1 and the...
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