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Article

The role of the PD-1/PD-L1 axis in macrophage differentiation and function during pregnancy

2 Nov 2018

Abstract excerpt

STUDY QUESTION: What is the role of the programmed cell death-1 (PD-1)/PD-1 ligand-1 (PD-L1) axis in macrophage polarization during early pregnancy? SUMMARY ANSWER: PD-1 signaling is a major regulator of macrophage differentiation and function, and it is critical for the success of a pregnancy. WHAT IS KNOWN ALREADY: The predominance of decidual macrophages (DMs) with an M2 phenotype is an important contributor...

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PMID: 30500923
DOI: 10.1093/humrep/dey347

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