Article
Biased mutational pattern and quasispecies hypothesis in H5N1 virus.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2013
Gutiérrez Ramona Alikiiteaga, Viari Alain, Godelle Bernard, Frutos Roger, Buchy Philippe
Abstract excerpt
Like other RNA viruses, influenza viruses are subject to high mutation rates. Carrying segmented RNA genomes, their genetic variability is even higher. We aimed at analyzing the mutational events occurring during the infection of chickens by the Highly Pathogenic Avian Influenza (HPAI) H5N1 virus. We therefore studied the different sequences of two surface proteins, hemagglutinin (HA) and neuraminidase (NA), as...
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