Article
A combined array-based comparative genomic hybridization and functional library screening approach identifies mir-30d as an oncomir in cancer.
Cancer research - 1 Jan 2012
Li Ning, Kaur Sippy, Greshock Joel, Lassus Heini, Zhong Xiaomin, Wang Yanling, Leminen Arto, Shao Zhongjun, Hu Xiaowen, Liang Shun, Katsaros Dionyssios, Huang Qihong, Bützow Ralf, Weber Barbara L, Coukos George, Zhang Lin
Abstract excerpt
Oncomirs are microRNAs (miRNA) that acts as oncogenes or tumor suppressor genes. Efficient identification of oncomirs remains a challenge. Here we report a novel, clinically guided genetic screening approach for the identification of oncomirs, identifying mir-30d through this strategy. mir-30d regulates tumor cell proliferation, apoptosis, senescence, and migration. The chromosomal locus harboring mir-30d was...
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