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Altered histone retention and epigenetic modifications in the sperm of infertile men

7 Nov 2011

Abstract excerpt

It is well know that the nuclei of spermatogenic cells experience one of the most extremely marked chromatin changes known in cells. At the end of spermatogenesis, the histones are removed in many species and the DNA is condensed by the highly positively charged protamines forming highly compact nucleoprotamine complexes.1, 2, 3 In the human mature sperm cell, the nucleoprotamine complexes condense most of the...

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PMID: 22057381
DOI: 10.1038/aja.2011.159

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