Article
Sperm GIRK2-containing K+ inward rectifying channels participate in sperm capacitation and fertilization.
Systems biology in reproductive medicine - 1 Dec 2011
Yi Young-Joo, Sung Dae Yong, Millette Clarke, Sutovsky Miriam, Kennedy Chelsey, Sutovsky Peter, Thompson Winston, Thomas Kelwyn
Abstract excerpt
The GIRK2-containing inward-rectifying K(+) ion channels have been implicated in mammalian spermatogenesis. While the Girk2 null mice are fertile, the male weaver transgenic mice carrying a gain-of-function mutation in the Girk2 gene are infertile. To establish the exact period of spermatogenesis affected by this mutation, we performed StaPut isolation and morphological characterization of the germ cells present...
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