Acrogranin, an acrosomal cysteine‐rich glycoprotein, is the precursor of the growth‐modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells

Abstract excerpt

Spermatogenesis is a unique system of differentiation involving cellular remodeling and the biogenesis of sperm-specific organelles. To study the biogenesis of one such organelle, the acrosome, we have been examining the gene expression, biosynthesis, and targeting of specific acrosomal proteins during mammalian spermatogenesis. An acrosomal marker that we recently purified and began characterizing is acrogranin,...

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