Article
The crystal structure of AphB, a virulence gene activator from Vibrio cholerae, reveals residues that influence its response to oxygen and pH.
Molecular microbiology - 1 Feb 2012
Taylor Jennifer L, De Silva Rukman S, Kovacikova Gabriela, Lin Wei, Taylor Ronald K, Skorupski Karen, Kull F Jon
Abstract excerpt
Expression of the two critical virulence factors of Vibrio cholerae, toxin-coregulated pilus and cholera toxin, is initiated at the tcpPH promoter by the regulators AphA and AphB. AphA is a winged helix DNA-binding protein that enhances the ability of AphB, a LysR-type transcriptional regulator, to activate tcpPH expression. We present here the 2.2 Å X-ray crystal structure of full-length AphB. As reported for...
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