Article
Survivin T9809C, an SNP located in 3'-UTR, displays a correlation with the risk and clinicopathological development of hepatocellular carcinoma.
Annals of surgical oncology - 1 Jul 2012
Hsieh Yih-Shou, Tsai Chiung-Man, Yeh Chao-Bin, Yang Shun-Fa, Hsieh Yi-Hsien, Weng Chia-Jui
Abstract excerpt
BACKGROUND: Early detection of hepatocellular carcinoma (HCC) is seldom available because of the lack of reliable markers. Survivin is an anti-apoptotic protein that is implicated in the regulation of apoptosis and cell cycle, and it is undetectable in normal adult tissues but is overexpressed in various types of cancers. Survivin is thus commonly considered to be a marker of malignancy. The aim of this study was...
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