Article
The survivin -31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival.
Analytical cellular pathology (Amsterdam) - 1 Jan 2010
Antonacopoulou Anna G, Floratou Konstantina, Bravou Vasiliki, Kottorou Anastasia, Dimitrakopoulos Fotinos-Ioannis, Marousi Stella, Stavropoulos Michalis, Koutras Agelos K, Scopa Chrisoula D, Kalofonos Haralabos P
Abstract excerpt
BACKGROUND: survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polymorphisms in CRC. In the present study, the mRNA levels of the five known isoforms of survivin as well as survivin...
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