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Article

The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors.

PloS one - 1 Jan 2011

Schmitt Kyle C, Reith Maarten E A

Abstract excerpt

Modafinil is a mild psychostimulant with pro-cognitive and antidepressant effects. Unlike many conventional stimulants, modafinil has little appreciable potential for abuse, making it a promising therapeutic agent for cocaine addiction. The chief molecular target of modafinil is the dopamine transporter (DAT); however, the mechanistic details underlying modafinil's unique effects remain unknown. Recent studies...

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Identifiers

PMID: 22043293
DOI: 10.1371/journal.pone.0025790
PMCID: PMC3197159

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