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Article

Role of arginine-56 within the structural protein VP3 of foot-and-mouth disease virus (FMDV) O1 Campos in virus virulence.

Virology - 5 Jan 2012

Borca Manuel V, Pacheco Juan M, Holinka Lauren G, Carrillo Consuelo, Hartwig Ethan, Garriga Damià, Kramer Edward, Rodriguez Luis, Piccone Maria E

Abstract excerpt

FMDV O1 subtype undergoes antigenic variation under diverse growth conditions. Of particular interest is the amino acid variation observed at position 56 within the structural protein VP3. Selective pressures influence whether histidine (H) or arginine (R) is present at this position, ultimately influencing in vitro plaque morphology and in vivo pathogenesis in cattle. Using reverse genetics techniques, we have...

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Identifiers

PMID: 22036313
DOI: 10.1016/j.virol.2011.09.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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