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Article

TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study.

Stroke - 1 Nov 2006

Sie Mark P S, Uitterlinden André G, Bos Michiel J, Arp Pascal P, Breteler Monique M B, Koudstaal Peter J, Pols Huibert A P, Hofman Albert, van Duijn Cornelia M, Witteman Jacqueline C M

Abstract excerpt

BACKGROUND AND PURPOSE: Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cardiovascular and cerebrovascular complications. Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine with a central role in inflammation. Little is known of the relation of variations within the gene and risk of cardiovascular and cerebrovascular disease. We therefore investigated 5...

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PMID: 17023672
DOI: 10.1161/01.STR.0000244779.30070.1a

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