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Transferable Plasmid-Mediated Resistance to Linezolid Due to <i>cfr</i> in a Human Clinical Isolate of Enterococcus faecalis

10 Apr 2012

Abstract excerpt

Nonmutational resistance to linezolid is due to the presence of cfr, which encodes a methyltransferase responsible for methylation of A2503 in the 23S rRNA. The cfr gene was first described in animal isolates of staphylococci, and more recently, it has been identified in Staphylococcus aureus from human clinical infections, including in an outbreak of methicillin-resistant S. aureus. In enterococci, cfr has been...

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PMID: 22491691
DOI: 10.1128/aac.00419-12

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