Article
DENSE: efficient and prior knowledge-driven discovery of phenotype-associated protein functional modules.
BMC systems biology - 24 Oct 2011
Hendrix Willam, Rocha Andrea M, Padmanabhan Kanchana, Choudhary Alok, Scott Kathleen, Mihelcic James R, Samatova Nagiza F
Abstract excerpt
BACKGROUND: Identifying cellular subsystems that are involved in the expression of a target phenotype has been a very active research area for the past several years. In this paper, cellular subsystem refers to a group of genes (or proteins) that interact and carry out a common function in the cell. Most studies identify genes associated with a phenotype on the basis of some statistical bias, others have extended...
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