Article
Chemogenomics approaches for receptor deorphanization and extensions of the chemogenomics concept to phenotypic space.
Current topics in medicinal chemistry - 1 Jan 2011
van der Horst Eelke, Peironcely Julio E, van Westen Gerard J P, van den Hoven Olaf O, Galloway Warren R J D, Spring David R, Wegner Joerg K, van Vlijmen Herman W T, Ijzerman Ad P, Overington John P, Bender Andreas
Abstract excerpt
Chemogenomic approaches, which link ligand chemistry to bioactivity against targets (and, by extension, to phenotypes) are becoming more and more important due to the increasing number of bioactivity data available both in proprietary databases as well as in the public domain. In this article we review chemogenomics approaches applied in four different domains: Firstly, due to the relationship between protein...
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