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Article

Significant Biological Role of Sp1 Transactivation in Multiple Myeloma

19 Aug 2011

Abstract excerpt

PURPOSE: The transcription factor specificity protein 1 (Sp1) controls number of cellular processes by regulating the expression of critical cell cycle, differentiation, and apoptosis-related genes containing proximal GC/GT-rich promoter elements. We here provide experimental and clinical evidence that Sp1 plays an important regulatory role in multiple myeloma (MM) cell growth and survival. EXPERIMENTAL DESIGN:...

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PMID: 21856768
DOI: 10.1158/1078-0432.ccr-11-1036

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